SARS2 and infection: To explore critical contact residues and mechanisms of escape that might be generated during the course of infection, we applied antibody selection pressure to replication-competent vesicular stomatitis virus (rcVSV) expressing the WA-1 SARS-CoV-2 spike (rcVSV-SARS2) (32) to identify spike mutations that confer in vitro resistance against A23-58.1, B1-182.1, A19-46.1, or A19-61.1 (fig.