In MM, adoptive cell transfer (ACT) using tumor-infiltrating lymphocytes (TILs), following a preconditioning non-myeloablative chemotherapy regimen and subsequent interleukin-2 (IL-2) treatment, has consistently induced objective clinical responses in 40%–50% of treated patients in multiple phase I/II trials, with complete response (CR) rates of up to 20%.6–9 The majority of patients achieving a CR experiences long-term benefit9 10; perhaps even cures. The gene discussed is IL2; the disease is Miyoshi myopathy.