High IL-8 has previously been shown to correlate with tumor burden in animal models and cancer patients,58 and a decrease in IL-8 was recently demonstrated to correlate with treatment response to checkpoint inhibitor treatment.59 High IL-10 production at the tumor site has been correlated with poor survival,60 and increased IL-10 after treatment with a vaccine, correlated with poor survival.61 This evidence concerns the gene CXCL8 and neoplasm.