BRAF-mutant human melanomas also have a lower mutational burden than NRAS-mutant melanomas, which is consistent with the fact that NRAS-mutant melanomas are enriched in CSD skin and older individuals, whereas BRAF-mutant melanomas are more common in younger individuals and areas of intermittent sun exposure (Long et al, 2011; Viros et al, 2014; The Cancer Genome Atlas, 2015; Conway et al, 2020). Here, BRAF is linked to melanoma.