MAPT and Alzheimer disease: Performance on each of the cognitive domain scores is presented as a function of PWV separately for AD biomarker+ and AD biomarker− participants (defined by the tau/Aβ42 ratio cutoff) in Fig. 2C. After adjusting for age, sex, education, and FSRP, there was a significant interaction between PWV and AD biomarker positivity on the memory domain score (interaction p = .01) reflecting a larger decrease in performance with increasing PWV for the AD biomarker+ participants than for the AD biomarker− participants.