KMT5A and Familial prostate cancer: For example, telomerase reverse transcriptase (TERT) stimulates EMT in colorectal cancer through inhibition of E-cadherin expression by binding to ZEB1 [36]; histone H4K20-specific methyltransferase SET8 stimulates EMT in prostate cancer by inhibiting E-cadherin transcription through binding to ZEB1 [37].