Here, we used clinical sample analysis to indicate that high expression of APE1 is closely associated with lymph node metastasis and low expression of E-cadherin in cervical cancer patients (Fig. 1), and in vitro functional experiments indicated that overexpression of APE1 significantly stimulates cervical cancer cell invasion, promotes the vimentin expression, and inhibits E-cadherin expression, while silencing of APE1 dramatically inhibits cervical cancer cell invasion (Fig. 2). This evidence concerns the gene VIM and cervical cancer.