Therefore, in the current study, we evaluated the efficacy of the MEK162/BKM120 combination to inhibit MEK and PI3K pathways and analyzed the effect on cell proliferation, apoptosis, and cell cycle distribution in a panel of three different human NSCLC cell lines selected according to their mutation and amplification status for EGFR, MET, KRAS, and PIK3CA genes. Here, EGFR is linked to non-small cell lung carcinoma.