Therefore, in the current study, we evaluated the efficacy of the MEK162/BKM120 combination to inhibit MEK and PI3K pathways and analyzed the effect on cell proliferation, apoptosis, and cell cycle distribution in a panel of three different human NSCLC cell lines selected according to their mutation and amplification status for EGFR, MET, KRAS, and PIK3CA genes. This evidence concerns the gene MAP2K7 and non-small cell lung carcinoma.