Some studies have shown that TBI may be associated with excess amounts of the proteins Aβ and phosphorylated tau (p-tau), which are also implicated in many neurodegenerative diseases.21,105 Preliminary evidence has demonstrated progressive and widespread tau pathology in mouse models of severe TBI106; however, tau pathology is not a simple phenotype, and the presence or absence of tau phosphorylation alone does not fully define tau pathology and may represent a transient effect of TBI. Here, MAPT is linked to neurodegenerative disease.