Alternative hypotheses have been proposed on the basis that the key factor in the development of AD is considered to be the aggregation of hyperphosphorylated tau protein (tauopathy), chronic inflammation of brain tissues (neuroinflammation), or the accumulation of mutations in mitochondrial DNA, leading to dysfunction of the mitochondrial respiratory chain and the development of oxidative stress [156,157,158]. Here, MAPT is linked to tauopathy.