WWOX and cancer: The gene that has come to be known as WWOX (WW-containing Oxidoreductase, Bednarek et al. [14]) was first located in the FRA16D region by Paige et al. [13] as HHCMA56, an oxidoreductase encoding sequence that had been deposited in GenBank in 1994 by Gmerek, R.E. and Medford, J.I. Paige et al. [13] had excluded HHCMA56 from contention on the basis of a PCR (D16S432E) that located (the final exon) of this gene hundreds of kilobases in distance from the “minimal homozygously deleted region in cancer cells” identified by Mangelsdorf et al. [12] and Paige et al. [13].