WWOX and neoplasm: Similarly to FHIT, WWOX contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the “non-classical tumour suppressor” behaviour of WWOX. Fragile sites, and the genes that span them, are therefore part of a protective response mechanism to oxidative stress and likely contributors to the differences seen in aerobic glycolysis (Warburg effect) in cancer cells [32,34].