In a study of triple-negative (negative status for ER, HER2 and progesterone receptor (PR)) BC (TNBC) across 3 independent sample cohorts, Mathe et al. found that IL6ST was one of only 4 genes that were differentially expressed between normal and BC tissues and which also differed in expression between TNBC and ER-positive (ER+) BC subtypes [40]. This evidence concerns the gene IL6ST and breast cancer.