The accumulation of neuritic plaques of hyperphosphorylated tau and β-amyloid proteins towards AD neuropathology follows a six-stage deposition pattern that begins in locus coeruleus [first stage], olfactory bulb, and entorhinal cortex (second and third stages, respectively), extending subsequently to the temporal cortex and other regions that are defined as higher stages [fourth, fifth, and sixth stages, respectively] of AD neuropathology [93]. The gene discussed is MAPT; the disease is Alzheimer disease.