SOD1 and amyotrophic lateral sclerosis: The WB analyses also confirmed the increased expression (by 20%) of the regulatory subunit 8 of the 26S proteasome (PSMD8) in hSOD1(G93A) astrocytes and the significantly higher amount (increased by 50%) of Gelsolin, a protein playing a central role in the actin dynamics of phagocytes [39], in ALS-related mutant astrocytes (Figure 4).