Following such principles, among the 20 under-expressed proteins, we chose GSTO1, a protein involved in the detoxification of several exogenous stressors [34], also found to be related to fALS [35], and GCLC, the rate-limiting enzyme involved in GSH biosynthesis, consistently with the finding of reduced GSH level in ALS [36,37,38]. This evidence concerns the gene GCLC and amyotrophic lateral sclerosis.