In this study we showed an increased phosphorylation of both IKKb and IkBα, and—accordingly—a higher amount of the NF-kB p65 subunit in the nucleus of hSOD1(G93A) astrocytes compared to non-ALS controls, sustaining its enhanced activation in ALS astrocytes. Here, NFKB1 is linked to amyotrophic lateral sclerosis.