The candidate common targets were principally enriched in pathways in cancer (hsa05200 and hsa05205), the HIF-1 signaling pathway (hsa04066), the TNF signaling pathway (hsa04668), the PI3K-Akt signaling pathway (hsa04151) and leukocyte transendothelial migration (hsa04670) (Table S7). Here, TNF is linked to cancer.