POLE and cancer: Recently, in endometrial cancer, four molecular subgroups have been identified by the cancer genome atlas (TCGA) and subsequently confirmed by other groups, POLE-mutated/ultramutated (POLE), microsatellite-instable/hypermutated (MSI), copy-number-low/p53-wild-type (p53wt) and copy-number-high/p53-mutated (p53mt), in addition to the histological subtype and grade [81,82].