The frequency of KIR3DL1 + HLA-Bw4 in the HCC group was 76.2% and significantly higher than the 60.9% observed in the non-HCC group (OR—2.05, 95% CI—1.09–3.85; p = 0.024, corrected p = 0.31). This evidence concerns the gene KIR3DL1 and hepatocellular carcinoma.