Kaplan–Meier analysis showed the cumulative incidence of HCC to be significantly higher in patients with KIR3DL1 + HLA-Bw4 positivity than in KIR3DL1 + HLA-Bw4-negative patients (log-rank test; p = 0.013) (Figure 1). The gene discussed is KIR3DL1; the disease is hepatocellular carcinoma.