In heart failure patients, the increased plasma levels of angiotensin II, due to the activation of the renin–angiotensin system, cause alteration on baroreflex control of sympathetic activity and HR directly in the vasomotor and cardiac centers in the brain and the peripheral nerve terminals, facilitating norepinephrine free and inhibiting acetylcholine release [30,31,32,33,34,35]. This evidence concerns the gene REN and heart failure.