The correlation between HCC development and reduced MTHFR activity has also been reported in the work of Li C. et al. [69], where the authors demonstrated that folate-deficiency conditions induced the upregulation of miR-149-5p and miR-22-3p and the inhibition of MTHFR expression in cancer cells, while maintaining protein levels in normal hepatocytes [69]. Here, MTHFR is linked to cancer.