Further experimental results showed that overexpression of miR-21-3p downregulated MAT2A and MAT2B genes by targeting their 3′-UTR, increased intracellular AdoMet levels, and induced apoptosis in HepG2 cells, providing evidence that miR-21-3p functions as a tumor suppressor and suggesting its therapeutic potential in HCC [71]. Here, MAT2A is linked to hepatocellular carcinoma.