They also found that the combination of AdoMet with miR-34a or miR-34c mimic increased acetylated forms of p53 and reduced the expression of histone deacetylase 1 (HDAC1) and silent mating type information regulation 2 homolog (SIRT1), two proteins whose expression correlates with cancer development and p53 stability, confirming the role of miR-34a and miR-34c as mediators of the proapoptotic effect of AdoMet. Here, TP53 is linked to cancer.