Recent findings pointed out the correlation between lncRNAs and AdoMet in diethylnitrosamine-induced HCC in rats, underlining how the administration of AdoMet at the beginning stages of HCC downregulated the expression of extra coding CCAAT/enhancer-binding protein alpha (ecCEBPA) and of urothelial carcinoma related 1 (UCA1) gene transcripts and ameliorated histopathological alterations through downregulation of the PI3K/Akt signaling pathway and upregulation of the antioxidant enzyme mRNA transcripts [86]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.