In 2006, Andreadis et al. demonstrated that ELISA analysis of Dsg3 and Dsg1 in the saliva is a highly sensitive and specific test that is suitable for diagnostic purposes, monitoring of disease activity and early detection of pemphigus relapses, as there is a high concordance between serum and salivary levels of the proteins [78]. Here, DSG3 is linked to pemphigus.