ROCK1 and breast cancer: When the action of melatonin in the programed cell death of mammary tumor was tested in in vitro and in vivo experiments, it was observed that melatonin and Y27632 reduced the expression of ROCK-1 and decreased cell viability, invasion, and migration either in cells capable of metastasizing (MCF-7) or in those that do not metastasize (MDA-MB-231) [62].