VEGFA and neoplasm: In tumors, lack of vessels, hypoxia, and nutrient deprivation trigger an angiogenic switch consisting in the expression of angiogenic promoters by tumor and stromal cells: VEGF, fibroblast growth factor (FGF), phosphogluconate dehydrogenase (PDG), lipoprotein A (LPA), and angiopoietins [25], allowing tumors to grow in size and to acquire metastatic potential [37].