We investigated serum ferritin, hepcidin, TREM2 and IL6 levels in ‘young DS’ (YDS, n = 23, 30–45 years) and ‘older DS’ (ODS, n = 24, 46–70 years) participants and then compared them with age-matched controls (young, YC, and old, OC, n = 25 in each group) using sandwich ELISA. This evidence concerns the gene TREM2 and Dravet syndrome.