ZEB1 and cancer: Even more consistent results were obtained for cells treated with DEX-CUR, suggesting an involvement in the epithelial-mesenchymal transition (EMT) of cancer cells, since ZEB-1 protein is one of the major regulators of EMT acting by two main pathways, namely, the down-regulation of epithelial proteins such as E-cadherins, and the over-expression of mesenchymal markers such as vimentin [43].