When calculating bone formation/resorption ratios (PINP/CTX-I and sRANKL/OPG), which better reflect bone turnover in RA, the PINP/CTX-I ratio increased significantly after 15 months of treatment compared to the baseline (p < 0.001; Table 4), reaching the same value as in healthy people (p = 0.469; Table 4). The gene discussed is TNFRSF11B; the disease is rheumatoid arthritis.