PD patients have a lower level of miR-26a in the cerebrospinal fluid in comparison to healthy subjects and the loss of miR-26a both in a PD mouse model and in PD patients led to an increase of Death-associated protein kinase 1 (DAPK1), that in turn, positively correlates with DA neuron synucleinopathy and death. This evidence concerns the gene DAPK1 and Parkinson disease.