The 4-methylene-2-octyl-5-oxotetra-hydrofuran-3-carboxylic acid (C75) and xanthenylacetic acid (XAA) for LPAR6 ameliorated hepatocellular carcinoma growth through modulating mitochondria homeostasis and arresting cancer cells at the G1-phase cell cycle [120]. The gene discussed is LPAR6; the disease is cancer.