LPAR1 and breast carcinoma: In breast cancer, overexpression of LPAR1 in MCF-10A mammary epithelial cells causes cells to acquire an invasive phenotype [38], which correlates with the heparin-binding EGF-like growth factor [39], and mediate basal breast metastasis through LPAR1-PI3K-ZEB1-miR-21 pathways [25].