Figure 1 illustrates the extracellular and intracellular biosynthesis of LPA. Consequently, aberrant ATX-LPA-LPAR axis may be involved in the development and progression of many pathologic conditions such as cancer and metastasis [6,7], radio- and chemo-resistances [8,9,10,11,12], fibrotic diseases [13], neuropathic pain [14], arthritis [15], metabolic syndromes [16], and atherosclerosis [17]. Here, ENPP2 is linked to cancer.