IL6 and Peri-Implantitis: Furthermore, Ghassib et al. conducted a systematic review and meta-analysis and reported that pro-inflammatory cytokines in peri-implant crevicular fluid, such as interleukin-1β and interleukin-6, can be used as adjunct tools to clinical parameters to differentiate healthy patients from peri-implant mucositis and peri-implantitis [9].