EIF4E and breast cancer: Interestingly, knocking down eIF4E can deplete 4E-BP4EBP1 from BC cells [102]; therefore, in addition to amplification of the EIF4EBP1 gene, the observed increase in it therefore suggests it is plausible that increased levels of 4EBP1 in ER+/8p11-p12+ BC cells may also be a result of elevated eIF4E [102].