Retinamides exhibited substantial anti-proliferative, anti-migratory/invasive (in vitro) and anti-growth (xenograft) properties in a range of AR-positve and -negative PC cell lines [147,148], suggesting that simultaneously inhibiting the AR and the MNKs can potentially be a new strategy against AR+ PC; this also implies that the MNK inhibitors (MNKis) may be useful in an AR-negative context. This evidence concerns the gene AR and pachyonychia congenita.