Similar to these findings in BC, Rebello et al. [169] found that the combination of two drugs (CX-5461 and CX-6258), two orally available agents which inhibit RNA polymerase I transcription and the PIM kinase respectively, exerted strong anti-proliferative and pro-apoptotic effects on both high c-Myc and PTEN-null murine prostate tumour models. This evidence concerns the gene PTEN and breast cancer.