Interestingly, targeting eIF4A influenced the BC transcriptome and translatome in a manner distinct from mTORi-mediated eIF4E inhibition [167], indicating that eIF4A and eIF4E may affect different subsets of messages in cancer cells and suggesting that concomitant targeting of eIF4A and eIF4E is a plausible combinatorial therapeutic strategy. Here, EIF4E is linked to breast cancer.