AR and hepatocellular carcinoma: In contrast to the findings described above, Zhang et al. recently demonstrated that knockdown of AR can trigger mTORC1 stimulation in hepatocellular carcinoma (HCC) cells MHCC-97L, as a result of downregulation of the classic AR target, FK506 binding protein 5 (FKBP5), which acts as an AKT/mTORC1 upstream inhibitor [119].