TRPM8 and breast cancer: Moreover, it has been shown that TRPM8, following menthol or icilin activation, regulates BC cell proliferation and migration via activation of AMP-activated protein kinase–Unc-51 like autophagy activating the kinase 1 (AMPK-ULK1) signaling pathway, suggesting that TRPM8, by regulating the autophagy, leads the proliferative and migratory processes [50].