Different studies have proven that p75NTR plays opposite roles in the context of different cancers, as it acts as a tumor suppressor in carcinomas of prostate, bladder, stomach and liver [20,21,22], whereas, in melanoma, pancreatic carcinoma, glioma and breast cancer, p75NTR acts as a tumor-promoting function facilitating survival and invasion of cancer cells [23,24,25]. This evidence concerns the gene NGFR and melanoma.