NGF and testicular neoplasm: In the present study, we aimed to investigate a new molecular pathway and found that the overexpression of p75NTR may have a pathogenetic role in testicular germ cell cancer development, which may occur in an NGF-independent manner [29,30], as confirmed by immunohistochemical Allred-score of negative NGF staining and its pro-survival receptor, TrkA, in tumoral tissue.