M1-like macrophages achieve this suppressing effect by recruiting CD8+ T and NK cells to the TME through antigen presentation to the T-cell receptor (TCR) [75] and the tumor-derived chemokine secretion of CXCL9, CXCL10, and CXCL11 to recruit and activate NK cells [76]. The gene discussed is CD8A; the disease is neoplasm.