CCR2 and hepatocellular carcinoma: For the S100A8 partnering protein S100A9, it was suggested that it is expressed by CCR2+ TAMs in hepatocellular carcinoma (HCC), where CCR2+ TAMs presented the same expression pattern as S100A9+ TAMs and were co-localized with CD31+ endothelial cells in areas of dense vascularisation [20].