Administration of imatinib after agonistic anti-CD40 antibody activated TAMs, redirected TAMs to antitumor M1 phenotype, by increased TNF and IL-6 production through the NFκB pathway along with decreased IL-10 production in mouse model of gastrointestinal stromal tumor GIST [250]. This evidence concerns the gene NFKB1 and gastrointestinal stromal tumor.