Using a mouse model of glioblastoma, massive infiltration of CD68+ macrophages with bubbly cytoplasm and increased expression of phagocytic cell markers (glycogen, glycoproteins, glycolipids, and mucins) were detected in Sparc-null tumors indicating that SPARC promotes phagocytosis of tumor cells [125]. The gene discussed is CD68; the disease is glioblastoma.