Thus, the Affymetrix microarray analysis of tumor and normal samples from patients with melanoma showed that S100A1 and S100A13 were expressed at a significantly higher levels in melanoma compared to normal skin tissue controls, while S100A2, S100A7, S100A8, S100A9, S100A10, and S100A11 were all highly expressed in primary melanoma samples compared to metastatic melanoma. This evidence concerns the gene S100A2 and melanoma.