SPARC polymorphisms c.*1200G > A (rs3210714) and c.331-59 A > C (rs7719521), genotypes AG + GG and AC + CC, respectively, were significantly associated with higher VEGF protein expression in breast cancer tissue compare to AA genotypes, which may explain the correlation with higher breast cancer risk and worse prognosis [194]. This evidence concerns the gene VEGFA and breast carcinoma.