SPARC deletion promoted ROS generation and increased the production of pro-inflammatory and pro-angiogenic cytokines IL-6, CCL2, VEGF, and TNF-α as well as cytokines with pro-migratory ability, CCL3, CXCL2, CSF-1, and M-CSF, accompanied by greater tumor infiltration by mac1-positive TAMs [119]. This evidence concerns the gene IL6 and neoplasm.