Tie2 (also known as Tek) was identified as an endothelium-specific tyrosine kinase receptor that regulates vascular maintenance (cell proliferation, migration, and stabilization), development of embryonic vascularization, and plays a significant role in pathological processes, such as tumor angiogenesis, atherosclerosis, and vascular leakage [130,131]. This evidence concerns the gene TEK and neoplasm.