The expression of M2-like macrophage markers Arg1, MRC1 and IL-10, CCL17, and CCL22 were down-regulated, and the expression of M1-like macrophage markers iNOS, IL-12, and TNFa were induced by cetuximab in modeled TAMs, treated with CM of colon cancer cells in vitro [241,242]. Here, TNF is linked to malignant colon neoplasm.