The genotypes ANGPT2 (rs3739391) GA/AA, ANGPT2 (rs3020221) CC, TEK (rs639225) GA/AA, and VEGF (rs2010963) CC was related to decreased OS in patients with head and neck squamous cell carcinoma treated with the combination therapy [198]. The gene discussed is ANGPT2; the disease is head and neck squamous cell carcinoma.