TNF and rheumatoid arthritis: Interestingly, genome-wide association studies (GWAS) identified single nucleotide polymorphisms (SNPs) in the region of chromosome 9 that contains the Mps One Binder Kinase Activator-Like 2B (MOBKL2B), C9orf72 and IFN-K loci as associated with the response to anti-tumor necrosis factor α therapy in rheumatoid arthritis (RA) [73], with a genetic predisposition to SLE [74] and recently as genetic loci shared between ALS and autoimmune diseases like SLE and RA [75].