A large non-coding hexanucleotide repeat expansion (HRE) in the C9orf72 gene (>30 up to 1000 units) is the main genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) [1,2], both characterized by neuroinflammation and high systemic levels of interleukin-6, interleukin-1β and tumor necrosis factor-α [3]. This evidence concerns the gene IL6 and frontotemporal dementia.