Gain of functions linked to the presence of the large HRE, resulting in nuclear RNA foci and cytoplasmic aggregation of dipeptide repeat proteins, are the main pathogenic mechanisms of neurodegeneration in FTD and ALS, but C9orf72 haploinsufficiency is assumed to play a role in the underlying neuroinflammation [13]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.