TNF-α, IL-1β, and IL-6 are the principal proinflammatory cytokines, and their expression levels were determined in many different types of inflammatory processes, including mastitis induced by lipopolysaccharide (LPS) [34,46], the inflammatory processes of rat testis induced by cadmium [45], and mouse sertoli cells induced by LPS [47]. This evidence concerns the gene IL6 and mastitis.