Notably, the development of Invariant NKT (iNKT) cells, which represent a subclass of NKT cells with regulatory functions, is orchestrated by TGF-β [106], and plays an important role switching from inflammation to resolution of liver injury [107], but also may affect the outcome and overall survival in HCC [108,109]. Here, TGFB1 is linked to hepatocellular carcinoma.