Prospero-related homeobox 1 (PROX1) plays pivotal roles in the embryonic formation of several organs and tissues, including liver, pancreas, eye, lymphatic vessel, nerve and cardiac muscle in mice [1,2,3,4] and a meta-analysis of a genome-wide association study revealed that the rs340874 SNP in the PROX1 gene is associated with type 2 diabetes reported in an animal model in which PROX1 heterozygous adult mice become obese and had higher serum insulin levels and hepatic lipid accumulation. This evidence concerns the gene INS and type 2 diabetes mellitus.