The medical significance of protein kinase B (AKT) and its associated signaling pathways is evidenced by numerous studies confirming AKT activation in various types of cancer, including kidney cancer [34], papillary thyroid cancer [35], nasopharyngeal cancer [36], squamous cell carcinoma of the esophagus [37], lung cancer [38], and advanced breast cancer [39]. The gene discussed is AKT1; the disease is esophageal squamous cell carcinoma.