In DA, five genes (AKT1, AKT3, GSK3β, EGFR, and PIK3AP1) showed a stronger correlation, in AA three genes (AKT3, GSK3β, and EGFR), while in GBM, only AKT3 showed a stronger correlation between mRNA and methylation in comparison to CNA. The gene discussed is AKT3; the disease is glioblastoma.