The PIK3AP1 gene, coding for TLR (toll-like receptor) adapter protein that links the AKT-mTOR signaling pathway via the PI3K kinase (phosphoinositide 3-kinase) [47], was hit by CNA in 8% of DA, 49% of AA, and 89% of GBM samples. This evidence concerns the gene MTOR and glioblastoma.