Most of the features associated with decreased PFS were also associated with diminished OS in a multivariate analysis: ECOG performance status (HR 1.39 (95% CI 1.12 to 1.74), p < 0.005), LDH levels (HR 1.23 (95% CI 1.01 to 1.48), p = 0.04), and bone metastasis (HR 1.94 (95% CI 1.29 to 2.92), p < 0.005), whereas PD-L1 negativity was nearly statistically significant (HR 2.08 (95% 0.99 to 4.35), p = 0.05). The gene discussed is CD274; the disease is bone metastasis.