This hypothesis is also confirmed by Heneka et al., who showed in APP/PS1 mice, that Aβ can activate NLRP3 inflammasome in microglia, inducing an inflammatory M1 phenotype, characterized by an elevated expression of proinflammatory factors, resulting in increased hippocampal and cortical Aβ deposition, neuronal loss, and cognitive impairment. This evidence concerns the gene NLRP3 and Cognitive impairment.