PIK3R2 and arhinia, choanal atresia, and microphthalmia: Consistent with a role for AKT signaling in velocity, directionality, and distance of migrations [44,45] and possible defects in NCSC migration in BAMS patients, we observed an upregulation of PIK3R2 involved in cell proliferation but matrix degradation [46] and downregulation of PIK3R1 that regulates cell migration.