PTPN11 and Noonan syndrome: Likewise, in BAMS, we observed a slight but non-significant decrease in PTPN11 expression (FC −0.69, p-value = 6.01 × 10−06), encoding SHP-2 that binds to PDGFRα and is also associated with facial dysmorphism in Noonan syndrome [58], further underlining the importance of this signaling pathway in BAMS.