In the Alzheimer’s disease pathway, 23 genes were mapped to the Alzheimer’s disease pathway including ATP synthase, H+ transporting, mitochondrial F0 complex subunits C1 (Atp5g1), C2 (Atp5g2), C3 (Atp5g3), F (Atp5j), epsilon (Atp5e), NADH dehydrogenase 1 alpha subcomplexes 11 (Ndufa11), 1 (ndufa1), 13 (ndufa13), NADH dehydrogenase 1 beta subcomplexes 2 (Ndufb2), 5 (Ndufb5), NADH dehydrogenase 1 unknown subcomplex (Ndufc1), and NADH dehydrogenase flavoprotein subcomplex (Ndufv3). The gene discussed is NDUFB5; the disease is early-onset autosomal dominant Alzheimer disease.