Many of these mammalian proteins are associated with neurodegenerative disorders, such as amyloid precursor protein in Alzheimer’s disease (AD), ataxin in amyotrophic lateral sclerosis (ALS), huntingtin in Huntington’s disease (HD) and a-synuclein in Parkinson’s disease (PD) (reviewed in [12]). The gene discussed is HTT; the disease is amyotrophic lateral sclerosis.