Although they did not find any associations of the three polymorphisms investigated (ZBTB38-RASA2—rs295301; miR-146a—rs2910164 and rs57095329) with sCJD susceptibility; the single nucleotide polymorphism (SNP) rs295301 did correlate with the appearance of myoclonus, while rs57095329 with mutism and the positive of cerebrospinal fluid protein 14-3-3 in sCJD patients. This evidence concerns the gene ZBTB38 and Myoclonus.