In addition to the relatively rare neuroendocrine gastrinomas, however, gastrin is also expressed locally in common cancers, for instance, in some brain tumors, most lung cancers, exocrine pancreatic cancers, gastric, colorectal and ovarian adenocarcinomas in which autocrine and/or paracrine gastrin may stimulate carcinogenetic growth [9,10,11,12,13,14]. This evidence concerns the gene GAST and cancer.