Well described TAA-responses are directed against alpha-fetoprotein (AFP), human telomerase reverse transcriptase (hTERT), glypican-3 (GPC3), melanoma-associated gene-A (MAGE-A), squamous cell carcinoma antigen recognized by T cells (SART), and New York-esophageal squamous cell carcinoma-1 (NY-ESO-1) [93,94,95,96,97,98]. Here, GPC3 is linked to esophageal squamous cell carcinoma.