Other clinical studies for HCC, e.g., IMMUTACE (TACE combined with nivolumab, NCT03572582), IMMULAB (RFA combined with pembrolizumab, NCT03753659), or IMMUWIN (selective internal radiation therapy (SIRT) combined with durvalumab (antibody specific for PD-L1), NCT04522544) are currently active to fathom loco-regional approaches with CPI. This evidence concerns the gene CD274 and hepatocellular carcinoma.