Sirtuin 1 (SIRT1) deacetylase is a multifunctional protein that has several genes implicated in many cellular pathways, including energy metabolism and stress response, among its targets—including TP53 and FOXOs. SIRT1 has been shown to be overexpressed in CML LSCs and to contribute to LSC resistance to TKIs [84,85]. This evidence concerns the gene SIRT1 and chronic myelogenous leukemia, BCR-ABL1 positive.