Promyelocytic leukemia (PML): the PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukaemia, encodes a protein localizing to nuclear bodies that acts as a tumor suppressor, controlling apoptosis, cellular proliferation and senescence [69] and negatively regulating mTOR [70]. The gene discussed is PML; the disease is acute promyelocytic leukemia.