In our study we considered only the main altered exons reported in literature of the three globozoospermia-associated genes (SPATA16, PICK1 and DPY19L2) and evaluated putative variants of these genes in a cohort of 18 unrelated men, including 10 patients affected by complete globozoospermia and eight patients affected by partial globozoospermia. The gene discussed is PICK1; the disease is Globozoospermia.