ROCK1 and myocardial infarction: Although the implications of both ROCK isoforms in tissue fibrosis, transgenic mice studies revealed that ROCK1 knockout or knockdown led to a marked attenuation of cardiac extracellular matrix remodeling in response to angiotensin-II, pressure overload or myocardial infarction, while ROCK1 overexpression caused spontaneous cardiac fibrosis [23,38,39,76].