RHOA and cardiac hypertrophy: For that reason, they were tested in MCT-induced PH and both aloperine [195] and 18β-GA [49] promoted protective with improvement in hemodynamics, cardiac hypertrophy and the attenuation of pulmonary vascular remodeling, possibly due to RhoA/ROCK regulation because of the reduction in protein and mRNA expression for RhoA, ROCK1 and ROCK2 [195].