SMARCA4 and pancreatic intraductal papillary-mucinous neoplasm: Other research showed that deletion of the Brahma-related gene 1 (Brg1), part of the chromatin remodeling SWI/SNF complexes in combination with Kras activation, promotes PDAC via IPMN formation in adult ductal cells, suggesting that the ductal cell is indeed the cell of origin for the small subset of IPMN-PDACs.