IL6 and neoplasm: Myofibroblast-like CAFs (myCAFs), which are mainly located in close proximity to cancer cells, are assumed to function as mechanical barriers that prevent cancer cell dissemination and tumor growth, whereas, another CAF population, the inflammatory subtype (iCAFs), located further away from the tumor cells, secretes factors such as IL-6, which are assumed to promote tumorigenicity [138,147] (Figure 3).