Schneider et al. showed elevated levels of IL-10, IL-6 and TNFα during the early trauma hemorrhage and blocking of IL-10 further increased IL-6 and TNFα levels after injury, indicating that IL-10 release may be part of the body’s natural defense process to counter-regulate the early-deranged immune mediators as means to attenuate post-injury SIRS [25]. Here, IL10 is linked to systemic inflammatory response syndrome.