The impact of deregulation of the NF-κB signaling pathway in RTT pathogenesis is further supported by the evidence that Irak1 over-expression causes impairment of dendritic-circuit complexity in cortical neurons, and that the genetically-induced correction of the aberrant NF-κB pathway in Mecp2-null animals ameliorates the dendritic morphogenic phenotype and lifespan [159]. This evidence concerns the gene NFKB1 and Rett syndrome.