ADCY4 and prostate carcinoma: Genistein was also reported to contribute to an antitumor effect on prostate cancer by reducing methylation and increasing the genes expression levels of ADCY4 encoding adenylate cyclase 4 and NEU1 encoding lysosomal sialidase that collectively governs the cell cycle, vasculogenesis, cellular immune response, and intracellular signaling (Table S6) [175].