Earlier, we showed that immunodepletion of the neuroprotective peptide, humanin, from the media of A549 and H1299 cells increased the relative abundance of oligomer vs. total levels of amyloid beta, a peptide involved in the Alzheimer disease process, and was correlated with diminished cell viability and increased apoptosis [56]. The gene discussed is MT-RNR2; the disease is early-onset autosomal dominant Alzheimer disease.