Treatment of A549 and H1299 cells with the PI3K inhibitor, AKT inhibitor, or NFκB inhibitor led to decreased levels of both MMP2 and MMP9 in the media (Figure 4), suggesting the likely involvement of these proteins in the mechanism regulating the levels of MMP2/9 in the media of these lung cancer cells. This evidence concerns the gene AKT1 and lung carcinoma.