Expression of KRASG12C in A549 cells has been previously shown to mediate its oncogenic signaling via the MAPK and PI3K/AKT/mTORC1/p70S6K signaling pathways [60,65] while disruption of the KRASG12S allele blocked AKT and ERK signaling pathways, inhibiting tumor growth and proliferation [65]. This evidence concerns the gene RPS6KB1 and neoplasm.